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Ankylosing Spondylitis Narrowing of the Sacroiliac (SI) joint and bone inflammation
Ankylosing Spondylitis Calcification of the SI joint
Ankylosing Spondylitis SI joint fusion
Ankylosing Spondylitis Ankylosing Spondylitis SI joints
Ankylosing Spondylitis Early Ankylosing Spondylitis bone inflammation
Ankylosing Spondylitis Bamboo spine
Ankylosing Spondylitis Ankylosing Spondylitis lumbar spine and SI joints (AP view)
Ankylosing Spondylitis Ankylosing Spondylitis lumbar spine (lateral view)
Ankylosing Spondylitis Bamboo spine explanatory metaphor
Ankylosing Spondylitis Ankylosing Spondylitis thoracic spine (lateral view)
Ankylosing Spondylitis Ankylosing Spondylitis Cervical Spine (Lateral View 1)
Ankylosing Spondylitis Ankylosing Spondylitis Cervical Spine (Lateral View 2)

 

  • Ankylosing spondylitis (AS) is an autoimmune disease of unknown aetiology.

  • It presents in young adults, often in an insidious manner with back pain and stiffness.

  • AS is a form of seronegative spondyloarthropathy.

  • It is an uncommon condition, with a prevalence of 0.05 - 0.23% in the general population.

  • It has been estimated that up to 90% of patients with AS possess the tissue antigen Human Leukocyte Antigen B27 (HLA B27).

  • AS only develops in 1% of individuals who have HLA-B27 antigen. The disease is thought to be triggered by an unrecognised environmental factor, in genetically predisposed individuals.

  • AS is an uncommon cause of back pain, however it is important to consider in the younger patient.

  • Early diagnosis and initiation of treatment, especially now with the use of TNF alpha drugs, can prevent severe fixed deformities of the spine and lar